Bangor serves as an uncongested transportation gateway to Canada, the Northeast and the Atlantic Seaboard. Bangor is located along highway routes to the northeast metropolitan areas and eastern Canada. Interstate 95, the major interstate highway that transits the Eastern Seaboard of the United States, crosses the City and is the major route to such urban centers as Portland (2 hours), Boston (4 hours), New York (7 hours), and the Canadian border (2 hours). Major state highways provide direct access to northern and eastern Maine, the Atlantic Provinces of Canada, northern New England, Quebec and upstate New York.

Bangor has immediate access to Interstate 95, several large trucking firms, convenient rail service, and a deep-water port an hour away.